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Year : 2016  |  Volume : 21  |  Issue : 2  |  Page : 159-164

Evaluating the effects of vitamin D and vitamin E supplement on premenstrual syndrome: A randomized, double-blind, controlled trial

1 Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran

Correspondence Address:
Elham Ebrahimi
School of Nursing and Midwifery, Hafte Teer Square, Shahroud
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1735-9066.178237

Clinical trial registration 201401086854N2

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Background: Premenstrual syndrome (PMS) can cause problems in daily work and relationships. Materials and Methods: Eighty-six women were randomly assigned to two intervention groups and one control group. Patients were asked to fill out the PMS Daily Symptoms Record for 2 months, and then the participants were randomly assigned to one of the three study groups. Medical intervention was carried out for 2 months with the participants in each group receiving either a tablet containing 200 mg vitamin D, 100 mg vitamin E, or a placebo each day, respectively. After 2 months, the results of pre- and post-intervention were compared. P < 0.005 was considered significant. Results: After the intervention, the mean score of the syndrome significantly decreased in all the three groups (12, 16, and 8 participants had decreased scores in vitamin D, vitamin E, and placebo, respectively). The differences between groups were not significant (P > 0.05). Conclusions: Supplemental therapy with vitamins D and E is an effective and affordable treatment for PMS.

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