|Year : 2016 | Volume
| Issue : 3 | Page : 331-336
The effects of progressive muscular relaxation and breathing control technique on blood pressure during pregnancy
Mahboobeh Aalami1, Farzaneh Jafarnejad2, Morteza ModarresGharavi3
1 Islamic Azad University of Mashhad, Mashhad, Iran
2 School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
3 Mashhad University of Medical Sciences, Mashhad, Iran
|Date of Submission||06-May-2014|
|Date of Acceptance||04-Nov-2015|
|Date of Web Publication||14-Apr-2016|
School of Nursing and Midwifery, Mashhad University of Medical Sciences, Ibn Sina Street, Mashhad
Source of Support: None, Conflict of Interest: None
Background: Hypertensive disorders in pregnancy are the main cause of maternal and fetal mortality; however, they have no definite effective treatment. The researchers aimed to study the effects of progressive muscular relaxation and breathing control technique on blood pressure (BP) during pregnancy.
Materials and Methods: This three-group clinical trial was conducted in Mashhad health centers and governmental hospitals. Sixty pregnant (after 20 weeks of gestational age) women with systolic BP ≥ 135 mmHg or diastolic BP ≥ 85 mmHg were assigned to three groups. Progressive muscular relaxation and breathing control exercises were administered to the two experimental groups once a week in person and in the rest of the days by instructions given on a CD for 4 weeks. BP was checked before and after the interventions. BP was measured before and after 15 min subjects' waiting without any especial intervention in the control group.
Results: After 4 weeks of intervention, the systolic (by a mean of 131.3 to 117.2, P = 0.001 and by a mean of 131.05 to 120.5, P = 0.004, respectively) and diastolic (by a mean of 79.2 to 72.3, P = 0.001 and by a mean of 80.1 to 76.5, P = 0.047, respectively) BPs were significantly decreased in progressive muscular relaxation and breathing control groups, but they were not statistically significant in the control group.
Conclusions: The interventions were effective on decreasing systolic and diastolic BP to normal range after 4 weeks in both the groups. The effects of both the interventions were more obvious on systolic BP compared to diastolic BP.
Keywords: Blood pressure, breathing exercises, hypertensive disorders, muscle relaxation, pregnancy complications, pregnancy-induced hypertension
|How to cite this article:|
Aalami M, Jafarnejad F, ModarresGharavi M. The effects of progressive muscular relaxation and breathing control technique on blood pressure during pregnancy. Iranian J Nursing Midwifery Res 2016;21:331-6
|How to cite this URL:|
Aalami M, Jafarnejad F, ModarresGharavi M. The effects of progressive muscular relaxation and breathing control technique on blood pressure during pregnancy. Iranian J Nursing Midwifery Res [serial online] 2016 [cited 2020 Jan 29];21:331-6. Available from: http://www.ijnmrjournal.net/text.asp?2016/21/3/331/180382
| Introduction|| |
Although pregnancy is one of the most pleasant situations in a woman's life, sometimes it is accompanied with diseases and problems such as increasing blood pressure (BP)., Pregnancy-induced hypertension has been defined as systolic BP of 140 mmHg and more or diastolic BP of 90 mmHg and more., BP increases after the first half of pregnancy in gestational hypertension and preeclampsia, but is differentiated from preeclampsia by the absence of proteinuria.
These disorders are the main cause of morbidity and mortality of fetus and mother across the world.,, Pregnancy hypertension is the most common type of these disorders whose incidence is 6–7% in primiparous and 2–4% in multiparous women. Gestational hypertension brings about several maternal and fetal complications such as increased fetal and neonatal mortality,,, preterm labor,, low weight for gestational age,,,, intrauterine growth restriction, abruption of placenta,, increased cesarean section delivery, heart and renal failure, and maternal death.
First pregnancy,,, aging,, high Body Mass Index before pregnancy,, 14, ,,, multiple pregnancies,,, race,,, diabetes,,, history of hypertension,, physical activity at the beginning of the pregnancy, and poor socio-economic status  are considered as the main risk factors and predisposing factors.
Although they are problematic, there is no definite effective treatment for these disorders., In most cases, delivery is recommended because of uncertainty of disorders. So far, no evidence has been found for improving gestational or fetal consequences by complete or relative bed rest.,, Changing diet has been also known to be ineffective in maternal–fetal improvement. One of the most common methods is medical treatment. It is still questionable as the protective effect of antihypertensive drugs for gestational hypertension and chronic hypertension in comparison with preeclampsia has not been confirmed.
However, the main question is about the etiology of an increase in BP in pregnancy., Some hypotheses have been recently suggested for the role of stress in preeclampsia and hypertensive disorders during pregnancy., The effect of stress in producing essential hypertension has been known clearly; however, it has not been confirmed in pregnancy, and the results of the studies are controversial.,,,
Homeostatic imbalance may lead to a huge number of stress-induced diseases by overstimulation of target organ. Therefore, self-regulatory treatments are useful treatments for stress-induced disorders. Relaxation techniques are used as an effective treatment for these kinds of disorders. The response to relaxation brings about homeostatic balance. Muscular tension decreases during relaxation, and peace of mind is achieved.
Nowadays, different methods of relaxation have been used. The most common ones are diaphragmatic breathing, meditation, imagery techniques, music therapy, massage therapy, progressive relaxation, hypnotism, autogenic training, and biofeedback. They are different in terms of the way of administration, and each one has special elements and differs highly from others. They are attractive economically as they are cheap.
A bulk of research ,, showed the effect of progressive muscle relaxation on essential hypertension; however, meta-analyses have demonstrated its low to average effect.,, But the effect of breathing control technique on chronic hypertension is more clear, and a decrease in BP has been observed in most cases by it., These findings are true for non-gestational hypertension, and no evidence has been found for pregnancy-induced hypertension. A study conducted in Helsinki (2006) reported that a significant decrease was observed in systolic BP and heart rate by progressive muscular relaxation in asthmatic pregnant women. An outdated study in London (1984) showed that the systolic BP measured during progressive muscular relaxation was lower than in the control group (the number of hospitalized women in the control group was significantly higher). However, muscular relaxation could not decrease diastolic BP significantly. According to the findings of this study, relaxation has a limited effect on decreasing gestational hypertension. In some studies, the effects of muscular relaxation during pregnancy  and breathing control technique on diastolic BP in non-pregnancy conditions were not found to be significant.
No study has investigated the effect of breathing techniques on gestational hypertension.
Researchers aimed to investigate and compare the effect of muscular relaxation and breathing control technique on decreasing BP during pregnancy with regard to the ambiguous influences of different relaxation methods. Furthermore, there are some other elements such as lack of enough studies on diastolic pressure, impact and expenses of antihypertensive drugs, lack of similar studies, and ease of performing these techniques that should not be neglected.
| Materials and Methods|| |
This is a three-group before-after clinical trial conducted in Mashhad Qaem, Imam Reza, and Omm-ol-banin hospitals and two gynecologists' offices during 2009–2010. Based on the data received monthly from health centers no. 1, no. 2, and no. 3, six sub-centers with higher numbers of hypertensive pregnant women were selected. Informed consent was obtained from all the participants. Inclusion criteria were systolic BP ≥135 mmHg or diastolic BP ≥85 mmHg, absence of severe preeclampsia [diastolic BP ≥110 mmHg, proteinuria ++ and more, headache, visual problems, upper abdominal pain, oliguria, an increase in serum creatinine and liver enzymes, thrombocytopenia, intrauterine growth restriction (IUGR), pulmonary edema] or eclampsia, absence of chronic hypertension or hypertension before 20 weeks, gestational age of 20–36 weeks, single pregnancy, no contraction or bleeding, absence of underlying diseases and mental disorders, absence of polyhydramnios, hydatidiform mole, and placenta previa, not being addicted to drugs, alcohol, mood-altering medicine, and cigarette, not using similar relaxation methods and breathing techniques during pregnancy, reading and writing literacy, and having a contact number. Exclusion criteria were using antihypertensive drugs (for experimental groups), complete bed rest, bleeding, contraction or leakage during the study, deterioration of preeclampsia to a severe form, hospitalization, starting medical treatments for experimental groups, subjects' decision to leave the study, being absent in one session of personal instructions in the experimental groups, not doing exercises of more than three sessions of relaxation and breathing control at home, occurrence of delivery during the 4-week intervention, and presence of symptoms such as confusion, fatigue, feeling of suffocation, pain, and blurred vision during doing exercises.
Subjects were selected using non-probable convenience sampling. They were randomly assigned to three groups. The order of the three groups was decided by drawing of lots. The first 10 were assigned to relaxation, the second 10 to breathing technique, and the third 10 subjects were assigned to the control group. It was repeated during the study. After a pilot study was conducted on 10 subjects of each group, the sample size was calculated by comparing the means formula (no. = 18 subjects in each group). Study continued until 20 subjects entered the study for more confidence and consideration of 10% more subjects, selected in sampling. In the relaxation group, two patients were excluded because of delivery, two because of their decision to leave the study, and one for starting medical treatments. In the breathing control group, four cases were excluded because of their decision to leave the study, two for delivery, and another one as she wanted to go on a vacation. In the control group, one subject was excluded for her decision to leave the study and another one as she wanted to go on a vacation.
Data collection tools were an interview form containing demographic and midwifery data, and a checklist for doing exercises in the class and at home.
In this study, two methods of progressive muscular relaxation and breathing control were compared. The researcher was trained by a psychologist to administer the techniques. It took 4 weeks for the subjects to do exercises in four classes that were held at Omm-ol-banin hospital. For the rest of the week, they followed researcher's oral instructions that had been recorded on a CD, at home. Continuation of doing exercises was followed by the phone calls. The symptoms of severe preeclampsia were checked both by phone calls and at the beginning of each personal class. In the personal classes, necessary explanations were given about doing exercises after the primary interventions and control of BP. The subjects were asked to empty their bladder and be in a convenient position (sitting or lying).
Progressive muscular relaxation was done using Jacobson method  by contracting and relaxing selected groups of muscles until total relaxation was achieved. Subjects were asked to contract and then relax their muscles including hands, different parts of face, shoulders, and other parts by the researcher's order. Each exercise session took around 20 min.
Breathing control technique included deep diaphragmatic breathing and decreasing the respiration rate to 6–10/min. Subjects were guided to do 20 deep diaphragmatic respirations, which took around 5 min.
No intervention was done in the control group. They received routine care given in the clinic or health center and used medications, if needed. In this group, the researcher checked the BP weekly for 4 weeks.
BP in all three groups was measured from the right hand at the level of the heart after 5 min, resting in a chair in sitting position. The first Korotkoff sound was regarded as the systolic BP and the last was considered as the diastolic BP.
Data were analyzed by one-way analysis of variance (ANOVA), Kruskal–Wallis, paired t-test, and Chi-square test through SPSS 11.5.
This survey was done as a part of a Master's degree thesis, registered in the site of clinical trial with the ID number NCT01664988. Mashhad University ethics committee approval has been obtained for this study.
| Results|| |
Three groups were matched and showed no significant difference in terms of jobs, socioeconomic class, body mass index, age, gestational age at their entry into the study, intended or unintended pregnancy, the number of deliveries, subjects' history of hypertensive disorders in their previous pregnancies or in their sister's or mother's, and taking calcium, iron, and multivitamin supplements.
Also, no significant difference was found between groups in systolic BP (P = 0.091) and diastolic BP (P = 0.400) at the beginning of the study. However, after 4 weeks of intervention, they were significant differences in progressive muscular relaxation (P = 0.000 for systolic BP, P = 0.001 for diastolic BP) and breathing control (P = 0.004 for systolic BP, P = 0.047 for diastolic BP) groups, but they were no statistically significant differences in the control group [Table 1].
In weekly comparison of BP before and after the intervention, the results were deliberating. In the progressive muscular relaxation group, the difference was significant for systolic BP from the first week and continued up to the end (week 4) [Table 2]. Although the decrease in diastolic BP was significant after week 4 [Table 1], in weekly comparison, it was significant just in the second week (P = 0.000) [Table 2]. The decrease in diastolic BP was significant before intervention at the first week, compared to after intervention in the 2nd, 3rd, and 4th weeks [Table 3].
|Table 2: Means of weekly pre- and post-interventional BPs in muscular relaxation group|
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|Table 3: Means of the first pre-interventional BP with weekly post-interventional BPs in the two interventional groups|
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In the breathing control group, the decrease in systolic BP was significant from the first week [Table 4]; however, the decrease in diastolic pressure was significant after intervention in the 3rd and 4th weeks [Table 4]. Comparison of the diastolic BP before intervention at the first week and after intervention (at 1st, 2nd, 3rd, and 4th weeks) showed a significant difference just in the 4th week [Table 3].
|Table 4: Means of weekly pre-interventional BPs with post-interventional BPs in the breathing control technique group|
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| Discussion|| |
This study aimed to compare the effects of progressive muscular relaxation and breathing control technique on BP during pregnancy. According to the results, systolic BP decreased not only after 4 weeks but also after the weekly intervention in the relaxation and breathing control groups, while it showed no significant decrease in the control group.
Both groups showed a significant decrease in diastolic BP after 4 weeks. In the progressive muscular relaxation group, it was significant in the 2nd session and in the breathing control group, it was significant in the 3rd and the 4th sessions, while it was not significant in the control group. So, it could be concluded that both techniques were effective on decreasing diastolic and systolic BP after 4 weeks.
Nickel et al., in their study conducted in Helsinki, aimed to study the effect of progressive muscular relaxation on the BP change, pulmonary parameters, heart rate, anger, and quality of life in asthmatic pregnant women and reported similar results. In their study, a significant decrease was observed in systolic BP and no result was reported for diastolic BP.
Little et al. in London aimed to detect the effects of relaxation with or without biofeedback in decreasing BP and preventing hospitalization and compared their effects on gestational consequences. They reported a decrease in systolic BP after 6 weeks, which is similar to the present study. Meanwhile, no difference was observed in diastolic BP, which is not in line with the present study.
Kaushik et al. reported results similar to the present study. They studied the effects of mental relaxation and slow breathing on essential hypertension. They concluded that both methods decreased systolic BP effectively; however, mental relaxation could not decrease diastolic BP. They found that slow breathing was more effective on decreasing BP, compared to mental relaxation.
Joseph et al. in Italy  showed that slow breathing could decrease systolic and diastolic BPs more than spontaneous breathing.
Findings of the present study are not consistent with the study of Urech et al. They compared immediate effects of two techniques of progressive muscular relaxation and mental imaging on mental secretive and cardiac functions of pregnant women in Switzerland. No significant change was observed in the intervention and control groups. Although they utilized a rapid method and one session of muscular relaxation, in our study, significant decreases were observed in systolic BP at the first session and in diastolic BP in some sessions.
It could also be concluded that just one session of muscular relaxation or breathing control is enough for decreasing systolic BP, but for decreasing diastolic BP, at least 2 weeks of muscular relaxation and 4 weeks of breathing control are necessary. In general, the effects of both techniques were more obvious on systolic BP compared to diastolic BP.
In both the two experimental groups, no subject needed a medical treatment; however, in the control group with no intervention, six patients underwent medical treatments due to high BP. Based on statistical analyses, a significant difference was found between the two intervention groups and the control group in terms of decreasing BP. It could be mentioned that the decrease in BP in the control group could be partly attributed to the medications. If the six patients taking medications in the control group are excluded, the difference between groups would become much more and the P value would decrease. Consequently, the sample size would decrease. Therefore, it was not statistically possible.
| Conclusion|| |
Our obtained results show that muscle relaxation and breathing control technique could be effective in decreasing the BP in hypertensive disorders during pregnancy.
This study is a result of a student's thesis. Thanks to Mashhad University of Medical Sciences for approving and supporting this research and to all the persons who cooperated in this study.
Financial support and sponsorship
This study supported by Mashhad University of Medical Sciences.
Conflicts of interest
There are no conflicts of interest.
| References|| |
James PR, Nelson-Piercy C. Management of hypertension before, during, and after pregnancy. Heart 2004;90:1499-504.
Cunningham FG, Leveno JJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Williams Obstetrics. 23rd
ed. United States: McGraw-Hill Companies; 2010. p. 706-56.
Mugo M, Govindardjan G, Kurukulasuria R, Sowers JR, McFaralane SI. Hypertension in Pregnancy. Curr Hypertens Rep 2005;7:348-54.
Roberts JM, Pearson G, Cutler J, Lindheimer M; NHLBI Working Group on Research on Hypertension During Pregnancy. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension 2003;41:437-45.
Amira OC, Okubadejo NU. Frequency of complementary and alternative medicine utilization in hypertensive patients attending an urban tertiary care centre in Nigeria. BMC Complement Altern Med 2007;7:30.
Gabbe SG. Obstetrics: Normal and Problem Pregnancies. Elsevier Health Sciences; 2007. p. 779-26.
Chen XK, Wen SW, Smith G, Yang Q, Walkera M. Pregnancy-induced hypertension is associated with lower infant mortality in preterm singletons. BJOG 2006;113:544-51.
Ananth CV, Basso O. Impact of Pregnancy-Induced Hypertension on Stillbirth and Neonatal Mortality. Epidemiology 2010;21:118-23.
Madadzadeh M, Feizi Z, Hagikazemi E, Haghani H. Mothers' hypertension and neonatal birth weight. Iranian J Neonatal 2005;18:17-26.
Miranda ML, Swamy GK, Edwards S, Maxson P, Gelfand A, James S. Disparities in maternal hypertension and pregnancy outcomes: Evidence from North Carolina, 1994-2003. Public Health Rep 2010;125:579-87.
Chen XK, Wen SW, Smith GN, Yang Q, Walker MC. New-onset hypertension in late pregnancy and fetal growth: Different associations between singletons and twins. Hypertens Pregnancy 2007;26:259-72.
Yücesoy G, Ozkan S, Bodur H, Tan T, Calişkan E, Vural B, et al
. Maternal and perinatal outcome in pregnancies complicated with hypertensive disorder of pregnancy: A seven year experience of a tertiary care center. Arch Gynecol Obstet 2005;273:43-9.
Everly GS Jr, Lating JM. The concept of stress. In: Everly GS Jr, Lating JM, editors. A Clinical Guide to the Treatment of the Human Stress Response. 2nd
ed. New York: Springer; 2002. p. 3-14.
Hernández-Díaz S, Werler MM, Mitchell AA. Gestational hypertension in pregnancies supported by infertility treatments. Role of infertility, treatments, and multipl gestations. Fertil Steril 2007;88:438-45.
Mikolajczyk RT, Zhang J, Ford J, Grewal J. Effects of interpregnancy interval on blood pressure in consecutive pregnancies. Am J Epidemiol 2008;168:422-6.
Poon LC, Nicolaides KH. First-trimester maternal factors and biomarker screening for Preeclampsia. Prenat Diagn 2014;34:618-27.
Vahidroodsari F, Ayati S, Ebrahimi M, Esmaily H, Shahabian M. The effect of prepregnancy body mass index on the development of gestational hypertension and preeclampsia. J Babol Univ Med Sci 2009;11:49-53.
Bhattacharya S, Campbell DM, Liston WA, Bhattacharya S. Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health 2007;7:168.
Turzanski Fortner SR. Modifiable Risk Factors for Hypertensive Disorders of Pregnancy among Latina Women: A Dissertation for the Degree of Doctor of Philosophy. Massachusetts, USA: University of Massachusetts; 2009. p. 1-96.
Tanaka M, Jaamaa G, Kaiser M, Hills E, Soim A, Zhu M, et al
. Racial disparity in hypertensive disorders of pregnancy in New York state: A 10-year longitudinal population-based study. Am J Public Health 2007;97:163-70.
Mastrogiannis DS, Spiliopoulos M, Mulla W, Homko CJ. Insulin resistance: The possible link between gestational diabetes mellitus and hypertensive disorders of pregnancy. Curr Diab Rep 2009;9:296-302.
Meher S, Abalos E, Carroli G. Bed rest with or without hospitalisation for hypertension during pregnancy (Review). Cochrane Database Syst Rev 2005;CD003514.
Todros T, Verdiglione P, Oggè G, Paladini D, Vergani P, Cardaropoli S. Low incidence of hypertensive disorders of pregnancy in women treated with spiramycin for toxoplasma infection. Br J Clin Pharmacol 2005;61:336-40.
Takiuti NH, Kahhale S, Zugaib M. Stress-related preeclampsia: An evolutionary aladaptation in exaggerated stress during pregnancy? Med Hypotheses 2003;60:328-31.
Leeners B, Neumaier-Wagner P, Kuse S, Stiller R, Rath W. Emotional stress and the risk to develop hypertensive diseases in pregnancy. Hypertens Pregnancy 2007;26:211-26.
Tarkhan M, Safarinia M, Khosh Sima P. Effectiveness of group stress inoculation training on the systolic and diastolic blood pressure and life quality of hypertension in women. Quarterly Journal of Health Psychology 2012;1:46-58.
Igosheva N, Taylor PD, Poston L, Glover V. Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptideY in adulthood. J Physiol 2007;582:665-74.
Roy-Matton N, Moutquin JM, Brown C, Carrier N, Bell L. The impact of perceived maternal stress and other psychosocial risk factors on pregnancy complications. J Obstet Gynaecol Can 2011;33:344-52.
Vollebregt KC, van der Wal MF, Wolf H, Vrijkotte TG, Boer K, Bonsel GJ. Is psychosocial stress in first ongoing pregnancies associated with pre-eclampsia and gestational hypertension? BJOG 2008;115:607-15.
Smith CA, Levett KM, Collins CT, Crowther CA. Relaxation techniques for pain management in labour. Cochrane Database Syst Rev 2011;CD009514.
Wolsko PM, Eisenberg DM, Davis RB, Phillips RS. Use of mind-body medical therapies. J Gen Intern Med 2004;19:43-50.
Shinde N, Shinde KJ, Khatri SM, Hande D, Bhushan V. Immediate effect of Jacobson's progressive muscular relaxation in hypertension. Sch J App Med Sci 2013;1:80-5.
Anthony B, Boudreaux L, Dobbs I, Jamal S, Guerra P, Williamson JW. Can relaxation lower metaboreflex-mediated blood pressure elevations? Med Sci Sports Exerc 2003;35:394-9.
Bertisch SM, Wee CC, Phillips RS, McCarthy EP. Alternative mind-body therapies used by adults with medical conditions. J Psychosom Res 2009;66:511-9.
Astin JA, Shapiro SL, Eisenberg DM, Forys KL. Mind-body medicine: State of the science, implications for practice. J Am Board Fam Pract 2003;16:131-47.
Goldstein CM, Josephson R, Xie S, Hughes JW. Current perspectives on the use of meditation to reduce blood pressure. Int J Hypertens 2012;2012:578397.
Dickinson HO, Campbell F, Beyer FR, Nicolson DJ, Cook JV, Ford GA, et al
. Relaxation therapies for the management of primary hypertension in adults. Cochrane Database Syst Rev 2008;CD004935.
Grossman E, Grossman A, Schein MH, Zimlichman R, Gavish B. Breathing-control lowers blood pressure. J Hum Hypertens 2001;15:263-9.
Joseph CN, Porta C, Casucci G, Casiraghi N, Maffeis M, Rossi M, et al
. Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. Hypertension 2005;46:714-8.
Beddoe AE, Lee KA. Mind-body interventions during pregnancy. J Obstet Gynecol Neonatal Nurs 2008;37:165-75.
Nickel C, Lahmann C, Muehlbacher M, Pedrosa Gil F, Kaplan P, Buschmann W, et al
. Pregnant women with bronchial asthma benefit from progressive muscle relaxation: A randomized, prospective, controlled triall. Psychother Psychosom 2006;75:237-43.
Little BC, Hayworth J, Benson P, Hall F, Beard RW, Dewhurst J, et al
. Treatment of hypertension in pregnancy by relaxation and biofeedback. Lancet 1984;1:865-7.
Kaushik RM, Kaushik R, Mahajan SK, Rajesh V. Effects of mental relaxation and slow breathing in essential hypertension. Complement Ther Med 2006;14:120-6.
Urech C, Fink NS, Hoesli I, Wilhelm FH, Bitzer J, Alder J. Effects of relaxation on psychobiological wellbeing during pregnancy: A randomized controlled trial. Psychoneuroendocrinology 2010;35:1348-55.
[Table 1], [Table 2], [Table 3], [Table 4]
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