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ORIGINAL ARTICLE
Year : 2015  |  Volume : 20  |  Issue : 5  |  Page : 599-603

Effect of Olea ointment and Acetate Mafenide on burn wounds – A randomized clinical trial


1 Department of Research and Development, Farateb Science and Research Co., Yazd, Iran
2 Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3 Department of Surgery, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Correspondence Address:
Dr. Mohammad Jalili Manesh
Second Floor, Mahtab Building, Next to Meli Bank, Hajimehdi Alley, Imam, Hussein Square, Yazd
Iran
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Source of Support: Kurdistan University of Medical Sciences, Conflict of Interest: None declared.


DOI: 10.4103/1735-9066.164507

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Background: The main goals in treating burns are to accelerate tissue renovation and prevent infection. Topical antibiotics are used in the treatment of burns, but they can cause side effects. Recently, a traditional ointment (Olea) has been used in Iran in the treatment of burns. This study examines the effect of topical honey ointment in healing of burn patients. Materials and Methods: In this randomized controlled trial (RCT), 30 hospitalized patients selected by conventional sampling (10 in Olea group and 20 in Acetate Mafenide ointment group) were evaluated. Inclusion criteria were: having second-degree burns and body surface area equal to or < 40%. One group was treated using topical Olea ointment and the other with Acetate Mafenide ointment (8.5%). Chi-square, Fisher exact test, and Kaplan–Meier were used. Significance level was considered as P < 0.05. Results: None of the patients in the Olea group needed surgery for debridement, while in the second group, 13 patients (65%) needed debridement (P = 0.001). In the Olea group, 1 patient (10%) and in the second group, 19 patients (95%) had positive cultures after 7 days (P < 0.001). The mean time of granulation tissue formation in the Olea group was 12 days (10.3–13.6) and in the other group, it was 17 days (13.3–20.6) (P < 0.001). Conclusions: Olea ointment is a useful treatment for burns, and it can prevent infections, accelerate tissue repair, and facilitate debridement. Therefore, using this ointment is recommended for the treatment of burns.


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